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Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide y and proopiomelanocortin cells

Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes

Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe

Y2 receptor-selective agonist delays the estrogen-induced luteinizing hormone surge in ovariectomized ewes, but y1-receptor-selective agonist stimulates voluntary food intake